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Updated: Jan 29, 2026
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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Non-Thermal Plasma vs. Low-Level Laser Therapy for Recurrent Oral Ulcers: A Randomized Controlled Pilot Study.
Norma Guadalupe Ibáñez-Mancera1, Régulo López-Callejas2, Víctor Hugo Toral-Rizo3
1Interdisciplinary Center of Health Sciences Unidad Santo Tomás, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
Biomedicines
|January 28, 2026
Summary
Non-thermal plasma (NTP) shows promise for treating recurrent oral ulcers (ROUs). This pilot study found NTP accelerated healing and reduced pain significantly compared to low-level laser therapy and placebo, suggesting it
Area of Science:
- Plasma Medicine
- Dermatology
- Medical Devices
Background:
- Recurrent oral ulcers (ROUs) significantly impair quality of life.
- Current treatments for ROUs have limitations.
- Non-thermal plasma (NTP) is an emerging therapeutic modality.
Purpose of the Study:
- To evaluate the feasibility and preliminary efficacy of NTP for treating ROUs.
- To compare NTP with low-level laser therapy (LLLT) and placebo.
- To assess ulcer healing time and pain reduction.
Main Methods:
- A prospective, single-blinded, randomized pilot study with 50 ROU patients.
- Patients were assigned to NTP, LLLT, or placebo groups (2:2:1 ratio).
- Ulcer size, pain scores (VAS), and healing time were measured.
Main Results:
- NTP significantly accelerated healing by 5.5 days (vs. LLLT) and 7.1 days (vs. placebo) (p < 0.001).
- NTP provided superior and sustained pain relief, with patients asymptomatic by day 2 (p < 0.001).
- NTP was well-tolerated with no reported adverse events.
Conclusions:
- NTP is a potentially safe and effective treatment for recurrent oral ulcers.
- NTP demonstrated faster healing and superior pain relief compared to LLLT and placebo.
- Larger clinical trials are warranted to confirm these promising findings.
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