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Related Experiment Video

Updated: Jan 29, 2026

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Parameter-Determined Effects: Advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and

Qin-Ling He1,2, Yu Zhou2, Yang Liu2

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Bioengineering (Basel, Switzerland)
|January 28, 2026
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Summary

Transcranial focused ultrasound stimulation (tFUS) shows promise for neuromodulation. Clarifying ultrasound parameters is vital for its effective and safe clinical use in treating neurological disorders.

Keywords:
excitabilityinhibitionneuromodulationsafetytranscranial focused ultrasound stimulationultrasound parameters

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Physics

Background:

  • Transcranial focused ultrasound stimulation (tFUS) is an emerging non-invasive neuromodulation technique.
  • tFUS offers high spatial resolution for targeting deep brain structures.
  • It effectively modulates neural activity, inducing excitatory or inhibitory effects.

Purpose of the Study:

  • To systematically review the effects of different tFUS parameters on brain neural activity.
  • To clarify parameter-effect relationships for reliable and reproducible neuromodulation.
  • To discuss mechanisms and safety issues of tFUS for clinical applications.

Main Methods:

  • Review of existing literature on tFUS parameter effects.
  • Integration of findings from animal models and human clinical studies.
  • Analysis of ultrasound parameter combinations and their impact on neural excitability/inhibition.

Main Results:

  • Controversy exists regarding specific parameters for neural excitability/inhibition.
  • Significant variations in parameters across studies limit clinical translation.
  • Understanding parameter-effect relationships is crucial for tFUS efficacy.

Conclusions:

  • A systematic clarification of tFUS parameter-effect relationships is urgently needed.
  • This review provides a theoretical basis for tFUS treatments in neurological diseases.
  • Safe and effective clinical application of tFUS requires precise parameter selection.