Related Experiment Video
Updated: Jan 29, 2026
08:33
Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
7.9K
The Utility of a Small Animal Grip Strength Measurement Device as a Model for Studying Exercise-Induced Muscle Damage
Haruki Kobori1, Jiapeng Huang1, Yishan Tong1
1Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Antioxidants (Basel, Switzerland)
|January 28, 2026
Summary
A novel grip strength device effectively models exercise-induced muscle damage (EIMD) in mice. This model shows early aldolase release and oxidative stress, aiding EIMD research and interventions.
Area of Science:
- Exercise physiology
- Muscle damage research
- Biomedical engineering
Background:
- Exercise-induced muscle damage (EIMD) involves tissue damage and biochemical changes after strenuous exercise.
- Developing reliable animal models is crucial for understanding EIMD mechanisms and testing interventions.
Purpose of the Study:
- To assess a small animal grip strength device as a model for inducing and quantifying EIMD.
- To investigate biochemical, inflammatory, and oxidative stress markers post-exercise in this model.
Main Methods:
- Thirty-four male mice underwent a grip strength exercise protocol (50 tail-pull contractions).
- Groups were sacrificed at 2, 4, and 7 days post-exercise for analysis.
- Assessed plasma aldolase, inflammatory gene expression, oxidative stress markers (BAP, d-ROMs), and NF-kB.
Main Results:
- Plasma aldolase significantly increased at 4 days post-exercise (p < 0.01).
- Oxidative stress showed decreased BAP at 7 days and a trend of increased d-ROMs at 4 days.
- No significant changes in inflammatory gene expression were observed.
Conclusions:
- The grip strength model induces biochemical alterations consistent with EIMD, including oxidative stress.
- This model offers a quantitative approach for studying EIMD mechanisms and evaluating interventions.
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