Natural Compounds in Gastric Cancer Therapy: Molecular Mechanisms and Potential Treatment Options

Area of Science:

• Oncology
• Natural Product Chemistry
• Molecular Biology

Background:

• Gastric cancer (GC) is a major global health concern, necessitating novel therapeutic approaches beyond surgery.
• Natural polyphenols like curcumin (CUR) and resveratrol (RSV) are being investigated for their anticancer properties.
• Understanding their molecular mechanisms is crucial for developing effective GC treatments.

Purpose of the Study:

• To review the current applications and molecular mechanisms of curcumin and resveratrol in gastric cancer.
• To highlight the therapeutic potential and translational relevance of these compounds.
• To explore their role in enhancing conventional chemotherapy.

Main Methods:

• Literature review of studies on curcumin, resveratrol, and gastric cancer.
• Analysis of molecular mechanisms including apoptosis, cell cycle arrest, and inflammation.
• Evaluation of their impact on chemotherapy sensitivity and chemoresistance.

Main Results:

• Curcumin induces apoptosis, endoplasmic reticulum stress, and cell cycle arrest in GC cells.
• Resveratrol enhances apoptosis and exhibits anti-inflammatory effects in GC.
• Both compounds increase GC cell sensitivity to chemotherapy and mitigate chemoresistance.

Conclusions:

• Curcumin and resveratrol possess significant therapeutic potential for gastric cancer.
• Their combined use with standard therapies represents an innovative strategy for GC treatment.
• These natural compounds could shape future gastric cancer treatment paradigms.