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Progesterone Receptor Expression in the Human Enteric Nervous System.

Naemi Kallabis1, Paula Maria Neufeld1, Alexandra Yurchenko1,2

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Summary
This summary is machine-generated.

Progesterone receptors are present in the human enteric nervous system (ENS), showing sex and age variations. This discovery suggests hormonal influence on gut-brain communication and potential therapeutic targets for neurodegenerative disorders.

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age differencesenteric nervous system (ENS)gut–brain axishuman intestineneurodegenerative diseaseprogesterone receptorssex differencessteroid hormones

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Endocrinology

Background:

  • The enteric nervous system (ENS) is vital for gut-brain axis communication and overall health.
  • ENS dysfunction is linked to central neurodegenerative disorders.
  • Progesterone's neuroprotective effects in the CNS suggest a potential role in ENS physiology.

Purpose of the Study:

  • To map nuclear and membrane-bound progesterone receptors in the human ENS.
  • To investigate regional, sex, and age-related variations in receptor expression.
  • To explore the potential of targeting ENS progesterone receptors for therapeutic interventions.

Main Methods:

  • Immunofluorescence and Reverse Transcription-Polymerase Chain Reaction (RT-PCR) were employed.
  • Analysis was conducted on anatomically distinct intestinal regions.
  • Expression levels were assessed considering sex and age.

Main Results:

  • Classical nuclear progesterone receptors (PR-A/B) and PGRMC1 were consistently found in myenteric ganglion cells.
  • RT-PCR confirmed PR-A/B, PGRMC1, mPRα, and mPRβ expression with regional differences.
  • Significant sex-specific patterns and age-related downregulation of receptors were observed.

Conclusions:

  • This study details progesterone receptor expression in the human ENS, revealing sex- and age-dependent regulation.
  • Progesterone signaling in the myenteric plexus indicates a hormonal influence on gut-brain communication.
  • Targeting ENS progesterone receptors offers a novel peripheral approach for neurodegenerative CNS disorders.