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Related Experiment Video

Updated: Jan 29, 2026

Studying Orthodontic Tooth Movement in Mice

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

Cell Death in Orthodontic Tooth Movement: Recent Advances and Emerging Insights.

Fumitoshi Ohori¹, Hideki Kitaura¹, Aseel Marahleh^1,2

¹Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Miyagi, Japan.

International Journal of Molecular Sciences

|January 28, 2026

Summary

Regulated cell death (RCD) pathways, beyond apoptosis and necrosis, are crucial for orthodontic tooth movement (OTM). These diverse RCD mechanisms actively regulate bone remodeling, influencing both tooth movement and root resorption.

Keywords:

bone remodeling cell death cementoblast cementocyte orthodontic tooth movement osteoblast osteoclast osteocyte periodontal ligament root resorption

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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

Area of Science:

Biomedical Science
Cell Biology
Orthodontics

Background:

Orthodontic tooth movement (OTM) involves bone remodeling, traditionally linked to apoptosis and necrosis.
Recent research highlights diverse regulated cell death (RCD) pathways beyond conventional apoptosis and necrosis.
Understanding RCD is crucial for comprehending the cellular mechanisms of OTM.

Purpose of the Study:

To review and summarize the current knowledge on various RCD pathways involved in OTM.
To delineate the specific roles of different RCD mechanisms in cellular populations during tooth movement.
To explore the implications of RCD in bone remodeling and potential therapeutic targets for OTM.

Main Methods:

Literature review of recent advances in cell death research and OTM.
Analysis of distinct RCD pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis.
Examination of RCD involvement in periodontal ligament (PDL) cells, cementoblasts, cementocytes, and bone-related cells on compression and tension sides.

Main Results:

On the compression side of OTM, RCD pathways in PDL cells and other bone-related cells drive inflammation, bone resorption, and root resorption.
On the tension side, specific RCD pathways, particularly autophagy in PDL and osteocytes, promote osteogenesis and tissue repair.
Cell death is an active regulator, not just passive elimination, acting as a switch for alveolar bone remodeling during OTM.

Conclusions:

Diverse RCD pathways actively regulate cellular processes during orthodontic tooth movement.
Understanding these mechanisms offers new insights into tooth movement biology.
Targeting specific RCD pathways could enhance OTM efficiency and reduce adverse effects like root resorption.