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Related Concept Videos

Functions of Smooth Muscles01:23

Functions of Smooth Muscles

3.4K
Smooth muscles are an important type of muscle tissue that plays a vital role in the involuntary movements of internal organs. For example, they help regulate the movement of food through the gut and the flow of blood through the circulatory system.
Function of visceral smooth muscles
Visceral smooth muscle is found in the walls of all hollow organs, except the heart, and is a key player in the involuntary movements that drive the functioning of these internal organs. This tissue is arranged in...
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Smooth Muscle Contraction01:25

Smooth Muscle Contraction

7.7K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
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Structure and Organization of Smooth Muscles01:13

Structure and Organization of Smooth Muscles

8.6K
Smooth muscle tissue is a type of muscle tissue that can be found lining various vital organs in the human body, including the lungs, blood vessels, digestive tract, and respiratory tract. This type of tissue is responsible for regulating the movements of these organs, playing crucial roles in the functioning of various systems, including the vascular, digestive, respiratory, and urinary systems.
Structure of smooth muscle cell
Smooth muscle cells are spindle-shaped with tapering ends and a...
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Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

4.0K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
4.0K
GPCR Desensitization01:12

GPCR Desensitization

8.1K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

1.6K
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
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Related Experiment Video

Updated: Jan 29, 2026

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle
08:59

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle

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Integrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review.

Saptarshi Roy1, Vijaya Kumar Gangipangi1, Pravesh Sharma1

  • 1Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.

Cells
|January 28, 2026
PubMed
Summary

Airway smooth muscle cells drive asthma symptoms like airway hyperresponsiveness and remodeling. Targeting G protein-coupled receptors (GPCRs) in these cells offers promising therapeutic strategies for asthma management.

Keywords:
GPCRairway remodelingairway smooth muscleasthmabronchoconstrictioncalcium signaling

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Focal Ca2+ Transient Detection in Smooth Muscle
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Focal Ca2+ Transient Detection in Smooth Muscle

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Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses
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Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses

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Related Experiment Videos

Last Updated: Jan 29, 2026

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle
08:59

Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle

Published on: May 5, 2022

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Focal Ca2+ Transient Detection in Smooth Muscle
17:41

Focal Ca2+ Transient Detection in Smooth Muscle

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Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses
07:56

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses

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Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Pharmacology

Background:

  • Asthma is a complex respiratory disease characterized by airway remodeling (AR) and airway hyperresponsiveness (AHR).
  • Airway smooth muscle (ASM) cells are key mediators of bronchoconstriction and contribute significantly to asthma pathophysiology.
  • G protein-coupled receptors (GPCRs) play a crucial role in regulating ASM cell functions.

Purpose of the Study:

  • To review the multifaceted roles of ASM cells in asthma.
  • To elucidate the mechanisms of GPCR signaling in ASM.
  • To highlight therapeutic targets within ASM for asthma treatment.

Main Methods:

  • Comprehensive literature review of studies on ASM cells in asthma.
  • Analysis of signaling pathways, particularly GPCR-mediated calcium flux.
  • Examination of current and emerging therapeutic strategies targeting ASM.

Main Results:

  • ASM cells contribute to AHR, airway thickening, and AR through various mechanisms.
  • GPCR signaling, especially calcium flux, is central to ASM contraction, growth, and inflammatory responses.
  • Numerous GPCRs and non-GPCRs in ASM cells have been identified and linked to asthma pathophysiology.

Conclusions:

  • ASM cells are critical players in asthma development and progression.
  • Targeting GPCRs in ASM presents a viable therapeutic avenue for managing asthma.
  • Further research into ASM-specific signaling pathways can lead to novel asthma treatments.