Proceedings From the Minnesota Learning Health Systems Symposium: The Role of Academic Partnership and...

Nearly 25 years ago, the Institute of Medicine (now the National Academy of Medicine), envisioned the concepts of a learning health system (LHS) as a path to reduce the discordance between scientifically demonstrable effectiveness of medicine and actual health care delivery by conscientiously leveraging the experiences, perspectives, and priorities of patients and frontline clinicians. Whereas many of the National Academy of Medicine's aspirational deliverables have not been attained within the time frame anticipated, the value of an LHS has nonetheless been increasingly recognized and continues to gain momentum nationally and internationally. In November 2024, Mayo Clinic Health System organized an LHS symposium with research leaders from Mayo Clinic and the University of Minnesota. The goal was to strategize future collaborative statewide LHS efforts, building on past experiences and lessons learned. Building on a foundation of implementation science and de-implementation principles, attendees contemplated opportunities to collaborate along strategic priorities of Mayo Clinic Health System research, including health equity, rural and population health, artificial intelligence validation and stewardship, and cancer care. The University of Minnesota provided examples of the LHS infrastructure built to support tomorrow's researchers and health care leadership while contemplating feasible opportunities to build, fund, and sustain a statewide LHS infrastructure. Anticipated future obstacles for LHS were also explored.