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Updated: Jan 29, 2026
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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
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Fecal Microbiota Transplantation for Autism Spectrum Disorder in Children: Results from a Prospective Open-Label
Dominykas Varnas1, Arnas Kunevičius2, Aurelijus Burokas2
1Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
Medicina (Kaunas, Lithuania)
|January 28, 2026
Summary
Fecal microbiota transplantation (FMT) shows promise for improving gastrointestinal and caregiver-reported autism spectrum disorder (ASD) symptoms in children, though not core diagnostic measures. Further research is needed to confirm these findings.
Area of Science:
- Neuroscience
- Gastroenterology
- Microbiology
Background:
- Autism spectrum disorder (ASD) is a growing global concern.
- Gut microbiota dysbiosis is implicated in ASD.
- Limited data exists on fecal microbiota transplantation (FMT) for pediatric ASD.
Purpose of the Study:
- To evaluate colonoscopic FMT efficacy in children with ASD.
- To assess impact on gastrointestinal and ASD-related symptoms.
Main Methods:
- Prospective, single-center, open-label controlled study.
- 30 children with ASD underwent FMT or served as controls.
- Assessed using GSRS, ADOS, CARS, CBCL, and PGI-R scales.
Main Results:
- No significant difference in ADOS scores between groups at 8 weeks.
- FMT group showed improved CARS, PGI-R, CBCL Internalizing Problems, and GSRS.
- Improvements in CARS and PGI-R persisted at 6 months; CARS, GSRS, PGI-R sustained up to 18 months in the FMT group.
- No serious adverse events; three mild events reported.
Conclusions:
- Colonoscopic FMT improved short-term GI and caregiver-reported ASD symptoms, but not ADOS scores.
- Some benefits were long-term.
- Findings are exploratory due to lack of blinding and potential bias; larger RCTs are required.
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