Related Experiment Video
Updated: Jan 29, 2026
08:56
Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
Published on: February 10, 2020
7.6K
Advances in Corneal Tissue Engineering: Comparative Performance of Bioengineered Grafts in Animal Models.
Eduardo Anitua1,2, Mar Zalduendo1,2, Mohammad H Alkhraisat1,2,3
1Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria, Spain.
Medicina (Kaunas, Lithuania)
|January 28, 2026
Summary
Tissue engineering offers promising alternatives to donor corneal transplants for treating corneal opacity and vision impairment. Research highlights strategies for regenerating corneal layers, aiming to restore both anatomy and function.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Ophthalmology
Background:
- Corneal opacity is a leading cause of global blindness and visual impairment.
- Scar tissue formation is the primary cause of corneal opacity.
- There is a critical shortage of donor corneal grafts for transplantation.
Purpose of the Study:
- To provide an integrated overview of current corneal engineering strategies.
- To compare engineered corneas with healthy corneas.
- To identify strategies for creating functional corneal substitutes as alternatives to transplants.
Main Methods:
- Systematic review following PRISMA guidelines.
- Protocol registered with PROSPERO (ID: CRD420250654641).
- Focused on performance of bioengineered corneal grafts in animal models compared to healthy eyes.
Main Results:
- Gelatin methacrylate/PEGDA matrices with corneal cells show promise for epithelial regeneration.
- Decellularized corneas and ECM-based constructs are promising for stromal and epithelial regeneration.
- Silk fibroin and collagen scaffolds show potential for endothelial regeneration.
Conclusions:
- Tissue-engineered corneal substitutes show potential for treating corneal blindness.
- Regenerated cornea's optical and functional properties are crucial for clinical effectiveness assessment.
Related Concept Videos
00:49What is Genetic Engineering?
80.0K
Overview
80.0K
02:24Comparative Excretory Systems
26.6K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.6K
02:16Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
15.9K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.9K
02:26Comparing Copy Number Variations and SNPs
18.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.7K
02:59Animal Mitochondrial Genetics
9.2K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.2K
02:22Overview of Advanced Functional Groups
29.7K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K