Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-ray Crystallography02:18

X-ray Crystallography

26.1K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
26.1K
Histone Modification02:32

Histone Modification

16.1K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.1K
Acid Strength and Molecular Structure03:05

Acid Strength and Molecular Structure

33.0K
Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
33.0K
Masking and Demasking Agents01:19

Masking and Demasking Agents

3.6K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.6K
Administering Oxygen by Mask01:30

Administering Oxygen by Mask

2.3K
Administering Oxygen by Mask
Administering oxygen by mask is a common nursing intervention that provides supplemental oxygen to patients with respiratory distress or chronic lung conditions. This procedure involves delivering oxygen at a specified rate through a face mask connected to an oxygen source.
Equipment
The equipment necessary for this procedure includes:
2.3K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing <i>in situ</i> single-cell microbiological analysis through a microwell droplet array with a gradual open sidewall.

Lab on a chip·2023
Same author

Cost-Effective Droplet Generator for Portable Bio-Applications.

Micromachines·2023
Same author

Picoliter droplet array based on bioinspired microholes for in situ single-cell analysis.

Microsystems & nanoengineering·2021
Same author

A novel anti-virulence gene revealed by proteomic analysis in Shigella flexneri 2a.

Proteome science·2010
Same author

Delivery of siRNA therapeutics: barriers and carriers.

The AAPS journal·2010
Same author

Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial.

Chinese journal of integrative medicine·2010

Related Experiment Video

Updated: Jan 29, 2026

Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating
10:39

Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating

Published on: October 11, 2016

10.1K

The Influence of Mask Modification on Microneedle Strength in Deep X-Ray Lithography.

Jie Wang1, Yigui Li2, Lin Du3

  • 1School of Integrated Circuits and Communications, Suzhou Vocational Institute of Industrial Technology, Suzhou 215104, China.

Micromachines
|January 28, 2026
PubMed
Summary

Optimized hollow microneedle arrays enhance blood collection and drug delivery. Shape modification and precise hole placement significantly improve microneedle strength and flow rate.

Keywords:
LIGA processingaligned exposure methoddeep X-ray lithographyhollow microneedle arrayphotomask

More Related Videos

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.9K
Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.6K

Related Experiment Videos

Last Updated: Jan 29, 2026

Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating
10:39

Measurement of X-ray Beam Coherence along Multiple Directions Using 2-D Checkerboard Phase Grating

Published on: October 11, 2016

10.1K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.9K
Author Spotlight: Non-Surgical Treatment of Melasma&#8211; Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

1.6K

Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Microneedle arrays are crucial for minimally invasive applications like blood collection and drug delivery.
  • Optimizing microneedle design is essential for improving performance and reliability.

Purpose of the Study:

  • To investigate shape modification and hole position optimization for hollow microneedle arrays.
  • To enhance microneedle strength, sharpness, and flow rate for improved functionality.

Main Methods:

  • Fabrication of hollow microneedles using deep X-ray lithography with photomask shape modification.
  • Analysis of hole alignment and position optimization through experimental and simulation methods (ANSYS 10.0).
  • Proof-of-strength testing by inserting microneedles into polyimide film.

Main Results:

  • Photomask shape modification successfully increased microneedle strength and compensated for exposure-related defects.
  • Optimizing hole placement away from the tip center increased microneedle flow rate.
  • Optimal hole alignment determined with a 30 μm horizontal and 50 μm vertical offset from the tip center.

Conclusions:

  • The study successfully optimized hollow microneedle design for enhanced strength and performance.
  • The findings provide a framework for fabricating robust and efficient microneedle arrays for biomedical applications.
  • Optimized microneedles meet critical requirements for strength, sharpness, and effective fluidic transport.