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In Vivo Prostate Cancer Modelling: From the Pre-Clinical to the Clinical Setting.

Elisabete Nascimento-Gonçalves1, Tiago Azevedo1, Catarina Medeiros1

  • 1Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.

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Summary

Rat and zebrafish models are advancing prostate cancer (PCa) research. These models improve our understanding of PCa and accelerate the development of new treatments, bridging the gap between lab findings and clinical application.

Keywords:
carcinogenesisdrug developmentpreclinical researchprostateratzebrafish

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Area of Science:

  • Oncology
  • Translational Medicine
  • Animal Models

Background:

  • Prostate cancer (PCa) is a significant global health concern, driving the need for improved preclinical models.
  • Current models face limitations in translating research findings to clinical practice.
  • Evolution of PCa modeling from cell-based to complex systems highlights ongoing challenges.

Purpose of the Study:

  • To review the translational relevance of rat and zebrafish models in prostate cancer research.
  • To summarize historical and current advances in PCa modeling.
  • To explore how combining model systems can enhance clinical translation.

Main Methods:

  • Review of historical milestones and current advances in rat and zebrafish PCa models.
  • Analysis of the role of rat models in understanding carcinogenesis and drug evaluation.
  • Assessment of zebrafish models for tumor biology, metastasis, and personalized medicine.

Main Results:

  • Rat models have been crucial for evaluating approved PCa drugs like antiandrogens.
  • Zebrafish models offer advantages for high-throughput screening and personalized medicine approaches.
  • Combining multiple model systems is key to bridging the gap between research and clinical application.

Conclusions:

  • Rat and zebrafish models are vital for advancing prostate cancer research.
  • These models offer complementary strengths for understanding PCa and testing therapies.
  • Refined models are essential for more predictive and ethical PCa research.