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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

3.5K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Related Experiment Video

Updated: Jan 29, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

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Severe Asthma Exacerbations: From Risk Factors to Precision Management Strategies.

Marina Paredes1, Jeisson Osorio1, Alberto García de la Fuente2

  • 1Pulmonology Department, Hospital Clínic de Barcelona and Universitat de Barcelona, 08036 Barcelona, Spain.

Journal of Clinical Medicine
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Severe asthma exacerbations (SAEs) are complex. Biomarkers like blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) help personalize treatment for better outcomes.

Keywords:
biomarkerseosinophilic asthmaexacerbation-proneintensive caretreatment

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Murine Model of Allergen Induced Asthma
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Related Experiment Videos

Last Updated: Jan 29, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Murine Model of Allergen Induced Asthma
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Area of Science:

  • Pulmonology
  • Immunology
  • Clinical Medicine

Background:

  • Severe asthma exacerbations (SAEs) pose significant morbidity, mortality, and healthcare challenges.
  • A subset of patients experiences recurrent SAEs despite current treatments.
  • Understanding risk factors and phenotypes is crucial for managing these events.

Purpose of the Study:

  • To review risk factors, phenotypes, and biomarkers of SAEs.
  • To explore personalized acute management strategies for SAEs.
  • To analyze the role of Type 2 (T2) biomarkers in guiding treatment.

Main Methods:

  • Comprehensive literature review of clinical, inflammatory, and environmental drivers of SAEs.
  • Focused analysis on Type 2 (T2) biomarkers: blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO).
  • Evaluation of emerging evidence on biologic therapies for exacerbations.

Main Results:

  • SAEs exhibit heterogeneous causes and inflammatory profiles; infections, allergens, obesity, and comorbidities are key risk factors.
  • Type 2 (T2)-high SAEs respond better to corticosteroids and biologics than T2-low SAEs.
  • BEC and FeNO predict exacerbation risk and corticosteroid response; biologics like anti-IL-5 and anti-TSLP show potential in acute care.

Conclusions:

  • Biomarker-guided management can improve therapeutic precision and reduce overtreatment in SAEs.
  • Integrating phenotypic and endotypic assessments in acute care may enhance patient outcomes and resource utilization.
  • Further prospective trials are necessary to validate these personalized approaches.