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A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
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Menthol-Based Cream as a Novel Therapy for Diabetic Skin Wounds
Ana Júlia Vieira1, Fernando Pereira Beserra1, Gabriel Bacil Prata1
1Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Dr. Antonio Celso W Zanin Street, 250, Botucatu 18618-689, Brazil.
Pharmaceutics
|January 28, 2026
Summary
Menthol cream significantly accelerated skin wound healing in diabetic rats by reducing inflammation and oxidative stress. This natural compound shows promise for managing diabetic wounds effectively.
Area of Science:
- Biomedical Science
- Dermatology
- Endocrinology
Background:
- Diabetes mellitus significantly impairs skin wound healing.
- This impairment is linked to chronic inflammation and oxidative stress.
Purpose of the Study:
- To evaluate the efficacy of menthol in promoting skin wound healing in diabetic rats.
- To investigate menthol's anti-inflammatory and antioxidant effects in this context.
Main Methods:
- Type 1 diabetes induced in rats using streptozotocin.
- Skin wounds were created and treated with vehicle, insulin cream, or menthol cream.
- Wound healing, inflammatory markers, antioxidant activity, and gene/protein expression were assessed.
Main Results:
- Menthol cream reduced wound area by 94%.
- Menthol decreased pro-inflammatory cytokines (TNF-α, IL-6) and increased anti-inflammatory cytokine (IL-10).
- Menthol enhanced antioxidant enzyme activity, glutathione levels, and nitric oxide production, while modulating key gene and protein expressions.
Conclusions:
- Topical menthol accelerates skin wound healing in diabetic rats.
- Menthol exerts therapeutic effects via anti-inflammatory and antioxidant mechanisms.
- Menthol promotes cell proliferation, supporting its potential for diabetic wound management.
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