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Ligustilide: A Phytochemical with Potential in Combating Cancer Development and Progression-A Comprehensive and
Victória Dogani Rodrigues1, Mayara Longui Cabrini2, Eliana de Souza Bastos Mazuqueli Pereira3
1Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília 17519-030, São Paulo, Brazil.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
Summary
Ligustilide, a compound from Ligusticum chuanxiong, shows promise against cancer by inhibiting growth and inducing cell death. It may also overcome chemoresistance, offering a new therapeutic strategy.
Area of Science:
- Pharmacology and Natural Products
- Oncology
- Molecular Biology
Background:
- Cancer is a major global health issue with growing therapeutic resistance.
- Ligustilide, a compound from Ligusticum chuanxiong, exhibits anticancer properties.
- Drug resistance limits the efficacy of conventional cancer therapies.
Purpose of the Study:
- To review the anticancer potential of Ligustilide and its isomer, (Z)-Ligustilide.
- To analyze their mechanisms of action against various cancer types.
- To explore their role in overcoming chemoresistance.
Main Methods:
- Comprehensive literature review of preclinical studies on Ligustilide and (Z)-Ligustilide.
- Analysis of reported mechanisms including cell proliferation inhibition, apoptosis induction, and autophagy modulation.
- Examination of effects on drug sensitivity and epigenetic regulation.
Main Results:
- Ligustilide inhibits cancer cell proliferation and induces apoptosis.
- (Z)-Ligustilide enhances drug sensitivity and modulates epigenetic regulation.
- Both compounds show multifaceted anticancer effects, suggesting potential against chemoresistance.
Conclusions:
- Ligustilide and (Z)-Ligustilide demonstrate significant anticancer potential.
- Further research is needed to elucidate precise mechanisms, pharmacokinetics, and bioavailability.
- These compounds represent a promising avenue for novel cancer therapeutics and overcoming drug resistance.
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