Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

4.4K
Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.4K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Subviral Agents01:29

Subviral Agents

556
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
556
Group Therapy01:26

Group Therapy

423
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
423
Air-entraining Agents01:27

Air-entraining Agents

268
Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...
268
Frustration and Conflict: Approach-Approach, Approach-Avoidance01:20

Frustration and Conflict: Approach-Approach, Approach-Avoidance

527
Frustration occurs when people are obstructed or prevented from achieving a desired goal or fulfilling a perceived need. For example, when someone's input is ignored in a discussion, it can lead to feelings of frustration. Conflict, however, arises from opposing interests, goals, or actions. Conflicts can take various forms based on the nature of these opposing desires or goals.
One common type of conflict is the Approach–Approach Conflict. In this case, a person faces two desirable...
527

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Benign Nodular Smooth Muscle Proliferation of the Lung Mimicking Malignancy.

Interdisciplinary cardiovascular and thoracic surgery·2026
Same author

A multicentric prospective analysis of the management of edentulous jaw fractures in the elderly population: a World Oral Maxillofacial Trauma (WORMAT) project.

Oral and maxillofacial surgery·2026
Same author

Acute respiratory failure due to intercostal artery rupture and bilateral thoracic meningoceles in a patient with neurofibromatosis type 1: a case report.

British journal of neurosurgery·2026
Same author

Esophagopericardial fistula: a late complication of liver stereotactic body radiation therapy.

Indian journal of thoracic and cardiovascular surgery·2026
Same author

Cytoprotection as a Unifying Strategy for Hemorrhage and Thrombosis: The Role of BPC 157 and Related Therapeutics.

Pharmaceuticals (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 29, 2026

Technical Aspects of the Mouse Aortocaval Fistula
06:12

Technical Aspects of the Mouse Aortocaval Fistula

Published on: July 11, 2013

17.5K

Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System-Triple NO-Agent Approach

Goran Madzarac1, Tomislav Becejac1, Toni Penovic1

  • 1Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
PubMed
Summary

Stable gastric pentadecapeptide BPC 157 effectively reversed tracheocutaneous fistula progression in rats by modulating the nitric oxide (NO) system. This therapy promoted wound healing and resolved respiratory distress, demonstrating its potential therapeutic value.

Keywords:
BPC 157L-NAMEL-NAME+L-arginineL-arginineratstracheocutaneous fistula

More Related Videos

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.3K
Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
03:51

Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas

Published on: September 8, 2023

1.8K

Related Experiment Videos

Last Updated: Jan 29, 2026

Technical Aspects of the Mouse Aortocaval Fistula
06:12

Technical Aspects of the Mouse Aortocaval Fistula

Published on: July 11, 2013

17.5K
Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
03:56

Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention

Published on: April 26, 2024

1.3K
Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
03:51

Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas

Published on: September 8, 2023

1.8K

Area of Science:

  • Biomedical research
  • Gastroenterology
  • Wound healing

Background:

  • Tracheocutaneous fistulas present complex challenges in wound healing and systemic relations.
  • The role of the nitric oxide (NO) system in tracheocutaneous fistula course and resolution remains understudied.
  • Severe clinical manifestations include respiratory distress, failed healing, and significant weight loss.

Purpose of the Study:

  • To investigate the course of tracheocutaneous fistulas and their relationship with the NO system.
  • To evaluate the therapeutic efficacy of stable gastric pentadecapeptide BPC 157 in resolving tracheocutaneous fistulas.
  • To explore the interaction between BPC 157 and NO-modulating agents.

Main Methods:

  • A 7-day rat model of tracheocutaneous fistula was established.
  • Rats were treated with stable gastric pentadecapeptide BPC 157 (10 µg, 10 ng) via drinking water or intraperitoneally.
  • Concurrent administration of NO agents (L-NAME, L-arginine, or L-NAME+L-arginine) was employed.

Main Results:

  • Tracheocutaneous fistulas were associated with NO system dysregulation, with L-NAME aggravating and L-arginine ameliorating symptoms.
  • Control rats exhibited severe respiratory distress, failed wound healing, and significant weight loss.
  • BPC 157 therapy promoted rapid healing, fistula closure, reduced respiratory distress, and counteracted NO system imbalance and increased malondialdehyde (MDA) levels.

Conclusions:

  • Stable gastric pentadecapeptide BPC 157 acts systemically to reverse the course of tracheocutaneous fistulas in rats.
  • BPC 157 demonstrates therapeutic potential by interacting with and modulating the NO system.
  • The findings suggest BPC 157 as a promising agent for managing complex wounds and associated physiological disturbances.