Related Experiment Video
Updated: Jan 29, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Persistently Elevated Gamma Power and Delayed Brain Damage in Aged Rats Acutely Exposed to Soman Without Status
Taiza H Figueiredo1, Vassiliki Aroniadou-Anderjaska1,2, Marcio De Araujo Furtado1
1Department of Anatomy, Physiology, and Genetics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Abstract:
Aged animals or humans are more susceptible to permanent brain damage from status epilepticus (SE), making the selection of antiseizure medication even more crucial. This study compared the antiseizure and neuroprotective efficacy of midazolam with that of tezampanel combined with caramiphen in treating soman-induced SE in aged rats. A substantial proportion of soman-exposed aged rats did not develop SE, allowing us to also study this noSE group. SE duration within 24 h post-exposure was significantly longer in the midazolam than the tezampanel + caramiphen group, which was reflected in the EEG power integral. Spectral density analysis showed sustained increase in gamma-band power in the noSE group. Increased delta power in the SE groups lasted longer after midazolam. Body temperature decreased substantially only in the noSE and tezampanel + caramiphen groups. The midazolam group displayed severe neuropathology in the hippocampus and the amygdala 7 days to 6 months post-exposure, whereas the noSE and tezampanel + caramiphen groups exhibited only delayed amygdala damage. Thus, tezampanel + caramiphen has far superior neuroprotective efficacy than midazolam in aged rats. Increased gamma power is associated with seizure resistance; however, even in the absence of SE, delayed neuropathology can develop after a single acute organophosphate exposure.
More Related Videos
Related Concept Videos
Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
Nuclear Power
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Power
Elevation of Intermediate Points on Vertical Curves
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

