Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Shape and Texture of Coarse Aggregate01:25

Shape and Texture of Coarse Aggregate

681
Aggregate shape is classified based on the relative sharpness or roundness of the edges and corners. This classification includes categories like rounded, angular, elongated, and flaky, each with specific characteristics. Rounded aggregates, fully shaped by attrition, are typical of river or seashore gravel, while angular aggregates, such as crushed rock, have well-defined edges. Aggregates that are elongated and flaky are less desirable, as they can reduce the workability and strength of...
681
RNA Interference01:23

RNA Interference

28.0K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.0K
RNA Structure01:23

RNA Structure

79.0K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.0K
RNA Stability01:53

RNA Stability

35.7K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.7K
RNA Splicing01:32

RNA Splicing

60.6K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.6K
RNA Editing02:23

RNA Editing

9.9K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular recruitment and release using DNA host condensates.

Nanoscale horizons·2026
Same author

Light-Modulated Self-Assembly of Synthetic Nanotubes.

Nano letters·2025
Same author

Modular DNA origami-based electrochemical detection of DNA and proteins.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Protein Recruitment to Dynamic DNA-RNA Host Condensates.

Journal of the American Chemical Society·2024
Same author

Dynamic control of DNA condensation.

Nature communications·2024
Same author

Light-controlled growth of DNA organelles in synthetic cells.

Interface focus·2023
Same journal

Bioelectrode Healing via Engineered Electrode Reconstruction on Biofilms under Strong Acid and Ultrahigh Current Density.

Chem & bio engineering·2026
Same journal

Ultrarapid Purification of Manganese-52 from Chromium-52 Targets via Potentiostatic Anodic Dissolution and Chelation Ion Chromatography.

Chem & bio engineering·2026
Same journal

Nanoengineered All-Cellulose Bilayer Barrier Papers for High-Performance and Recyclable Food Packaging.

Chem & bio engineering·2026
Same journal

New Frontiers in AI-Nano Converged Platforms for Intelligent Diagnostics, Therapeutics, and Safety Evaluation.

Chem & bio engineering·2026
Same journal

Strategies for Mitigation of Intermediate CO<sub>2</sub> Poisoning to Promote Electrocatalytic Efficiency during Urea Oxidation Reaction.

Chem & bio engineering·2026
Same journal

Modular Biosurface Engineering of Magnetotactic Bacteria for Multimodal Synergistic Cancer Therapy.

Chem & bio engineering·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K

Coarse-Grained Modeling and Simulation of Multistranded RNA Nanostars.

Pradnya R Kadam1, Justine Lim1, Mahdi Dizani1

  • 1†Department of Molecular, Cell, and Developmental Biology, ‡Department of Computational and Systems Biology, §Department of Mechanical and Aerospace Engineering, ∥Department of Bioengineering, ⊥Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, United States.

Chem & Bio Engineering
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Synthetic RNA nanostars, inspired by biomolecular condensates, show tunable geometry and flexibility. Arm number, salt, and temperature influence their structure, aiding in designing novel RNA-based materials.

Keywords:
RNA nanostarsRNA nanotechnologycoarse-grained molecular dynamicsnucleic acid nanotechnologyphase separationsynthetic condensates

More Related Videos

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain
07:10

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain

Published on: March 13, 2020

10.7K
Author Spotlight: Evaluating Clinicians' Adoption of Ultrasound-Guided Vascular Cannulation Through Simulation Training
05:04

Author Spotlight: Evaluating Clinicians' Adoption of Ultrasound-Guided Vascular Cannulation Through Simulation Training

Published on: August 9, 2024

1.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K
Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain
07:10

Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics Analysis of Wheat Grain

Published on: March 13, 2020

10.7K
Author Spotlight: Evaluating Clinicians' Adoption of Ultrasound-Guided Vascular Cannulation Through Simulation Training
05:04

Author Spotlight: Evaluating Clinicians' Adoption of Ultrasound-Guided Vascular Cannulation Through Simulation Training

Published on: August 9, 2024

1.5K

Area of Science:

  • Biophysics
  • Synthetic biology
  • Materials science

Background:

  • Biomolecular condensates regulate cellular processes via phase separation.
  • Synthetic RNA nanostars offer a modular platform for engineering these condensates.

Purpose of the Study:

  • Quantify the conformational dynamics of 3-, 4-, and 5-arm RNA nanostars.
  • Investigate the effects of valency, salt concentration, and temperature on nanostar geometry and flexibility.

Main Methods:

  • Coarse-grained modeling
  • Molecular dynamics (MD) simulations using the oxRNA2 platform

Main Results:

  • Increasing arm number reduced mean interarm angle but maintained flexibility.
  • Salt and temperature influenced geometry and flexibility differently across nanostar valencies.
  • RNA nanostars showed distinct geometric preferences compared to DNA nanostars.

Conclusions:

  • Valency, salt, and temperature are key factors in controlling synthetic RNA nanostar properties.
  • These findings inform the rational design of RNA nanostars for predictable material responses in engineered condensates.