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Patient-Related Risk Factors for Mesh Erosion Following Midurethral Sling Procedures: A Systematic Review and
Tyas Priyatini1, Akbar Novan Dwi Saputra2,3, Alfa Putri Meutia1
1Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Introduction And Hypothesis:
Midurethral slings (MUS) are among the most commonly performed surgical treatments for stress urinary incontinence (SUI) worldwide, but mesh erosion remains a concerning complication. This systematic review and meta-analysis aimed to identify patient-related risk factors associated with mesh erosion following MUS procedures.
Methods:
We conducted a comprehensive literature search in MEDLINE via PubMed, ScienceDirect, and Scopus from January 2010 to March 2025. Studies reporting risk factors for mesh erosion following synthetic MUS procedures for SUI were included. Two independent reviewers assessed study quality using the Newcastle-Ottawa Scale. Evidence certainty was evaluated using the GRADE approach. Fixed-effects meta-analyses were performed to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs).
Results:
Six high-quality studies (n = 3068 patients) were included. The prevalence of mesh erosion ranged from 1.3% to 13.7% across studies. Significant risk factors for mesh erosion included prior pelvic surgery (OR 10.37; 95% CI 6.70-16.07), diabetes mellitus (OR 4.63; 95% CI 3.44-6.25), smoking (OR 3.38; 95% CI 2.54-4.48), obesity (BMI ≥ 30 kg/m2) (OR 2.79; 95% CI 1.69-4.62), and postmenopausal status (OR 2.34; 95% CI 1.67-3.27). GRADE assessment indicated moderate-certainty evidence for prior pelvic surgery, diabetes mellitus, smoking, and postmenopausal status.
Conclusions:
This meta-analysis identifies prior pelvic surgery, postmenopausal status, diabetes mellitus, smoking, and obesity (BMI ≥ 30 kg/m2) as significant risk factors for mesh erosion following MUS procedures. These findings provide an evidence-based foundation for preoperative risk stratification and patient counseling.
Trial Registartion:
Prospero CRD420251026364.
Insights
Patient factors like prior pelvic surgery, diabetes, smoking, obesity, and postmenopausal status increase the risk of mesh erosion after midurethral sling (MUS) procedures for stress urinary incontinence (SUI). Understanding these risks aids in patient counseling and surgical planning.
Area of Science:
- Urology
- Gynecology
- Surgical Complications
Background:
- Midurethral slings (MUS) are a common surgical treatment for stress urinary incontinence (SUI).
- Mesh erosion is a significant complication associated with MUS procedures.
- Identifying patient-related risk factors is crucial for improving surgical outcomes.
Conclusions:
- Prior pelvic surgery, postmenopausal status, diabetes mellitus, smoking, and obesity are significant risk factors for mesh erosion after MUS.
- These findings are essential for preoperative risk assessment and informed patient counseling.
- Further research may refine risk stratification and management strategies for SUI patients undergoing MUS.
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