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Updated: Jan 30, 2026

Direct Comparison of Hyperspectral Stimulated Raman Scattering and Coherent Anti-Stokes Raman Scattering Microscopy for Chemical Imaging
Published on: April 28, 2022
Single-particle surface-enhanced coherent anti-Stokes Raman scattering: Nanoparticle design and mechanism
Sanjun Fan1, Ran Cheng2, Haonan Lin3
1Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Abstract:
Surface-enhanced coherent anti-Stokes Raman scattering (SECARS) is believed to increase the signal intensity and sensitivity by combining the localized surface plasmon resonance and coherent Raman enhancement. However, the realization of SECARS is more complex than for surface-enhanced Raman scattering (SERS) and remains challenging. Unlike SERS, the nonlinear CARS process requires the coherent interaction of three distinct fields. The interactions between the electric fields and nanoparticle (NP) morphology for single-particle SECARS remain unexplored, and the underlying mechanisms generating the SECARS signal are not fully understood. Here, 27 distinct NPs were synthesized and screened using a CARS microscope. Among them, only star-core core-satellite NPs show single-particle SECARS signals, which were affected by laser polarization, two-photon luminescence background, photoinduced heating effects, particle size, and particle morphology. The influence of NP properties on SECARS enhancement offers guidance for the design and synthesis of NPs for single-particle SECARS and opportunities in biological imaging and chemical sensing.
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10:59Author Spotlight: Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy
Published on: May 12, 2023
12:56Differential Imaging of Biological Structures with Doubly-resonant Coherent Anti-stokes Raman Scattering CARS
Published on: October 17, 2010
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