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Updated: Jan 30, 2026

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
Published on: November 23, 2012
Substitution matters: Comparison of four N,1,4-tri(methoxy-2-hydroxybenzyl)-DAZA ligands as potential PET/CT liver
Anne Zenner1, Thomas Winkens1, Marta Pomraenke1
1Jena University Hospital, Working Group for Translational Nuclear Medicine and Radiopharmacy, Clinic of Nuclear Medicine, Am Klinikum 1, 07747 Jena, Friedrich Schiller University Jena, Germany.
Abstract:
Four regioisomers of [68Ga]Ga-TMoS-DAZA, a PET/CT radio tracer for liver function imaging, were studied as candidates of potentially improved hepatobiliary biokinetics. Liver uptake and biliary clearance behavior were compared using an in ovo model based on ostrich eggs for PET/CT imaging and ex vivo biodistribution analysis. The tracer lipophilicity was evaluated via logD determination. The experiments showed remarkable differences between the four tracers concerning their maximum liver uptake, percentage of tracer cleared via the biliary tract and their respective logD values.
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