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Sigma's Non-specific Protease Activity Assay - Casein as a Substrate
Published on: September 17, 2008
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A 168 dB FoM ISFET-Integrated CT Delta Sigma Frontend With Gm-Boosted Linearity and Hybrid Noise Shaping Achieving
IEEE Transactions on Biomedical Circuits and Systems
|January 28, 2026
Summary
This study introduces a novel low-power frontend architecture integrating an ion-selective field-effect transistor (ISFET) with a continuous-time delta-sigma modulator (CT-ΔΣM) for enhanced biochemical sensing. The design achieves high accuracy and low power consumption, improving upon existing ISFET frontends.
Area of Science:
- Biomedical Engineering
- Integrated Circuit Design
- Sensor Technology
Background:
- Ion-selective field-effect transistors (ISFETs) are crucial for biochemical sensing.
- Existing ISFET frontends often face challenges with power efficiency and integration complexity.
- Continuous-time delta-sigma modulators (CT-ΔΣM) offer high resolution for analog-to-digital conversion.
Purpose of the Study:
- To present a low-power, ISFET-integrated frontend architecture.
- To improve energy efficiency by directly merging the ISFET with the CT-ΔΣM.
- To enhance the performance of biochemical sensing systems.
Main Methods:
- Direct integration of ISFET as both sensor and integrator input stage.
- Utilizing a Gm-C based CT-ΔΣM architecture.
- Incorporating a passive low-pass filter DAC (LPF-DAC) for noise shaping.
- Employing source degeneration and gm-boost techniques for linearity.
Main Results:
- Achieved a peak Signal-to-Noise and Distortion Ratio (SNDR) of 84.2 dB.
- Measured a dynamic range of 90.4 dB over a 10 kHz bandwidth.
- Demonstrated ultra-low power consumption of 41.5 µW.
- Obtained a Schreier Figure of Merit (FoM) of 168 dB, an 8 dB improvement.
- Exhibited an averaged sensitivity of 29.04 mV/pH and a resolution of 6.8 m-pH.
Conclusions:
- The proposed ISFET-integrated CT-ΔΣM frontend offers superior performance and energy efficiency.
- The architecture is well-suited for low-power, high-accuracy biochemical sensing applications.
- This design represents a significant advancement over previous ISFET frontend solutions.
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