Assessment of genetically modified soybean GMB151 × DAS-44406-6 (application GMFF-2024-21774, EFSA-Q-2024-00330)

Area of Science:

• Agricultural Biotechnology
• Genetics and Molecular Biology
• Food and Feed Safety

Background:

• Genetically modified soybean GMB151 × DAS-44406-6 combines two previously assessed single-event soybeans.
• This two-event stack soybean expresses multiple proteins for enhanced traits.

Purpose of the Study:

• To assess the food, feed, and environmental safety of the combined genetically modified soybean GMB151 × DAS-44406-6.
• To evaluate potential risks associated with the novel combination of genetic events and expressed proteins.

Main Methods:

• Molecular characterization of the two-event stack soybean.
• Comparative analysis of agronomic, phenotypic, and compositional characteristics.
• Toxicological, allergenicity, and nutritional assessments.

Main Results:

• No food, feed, or nutritional safety concerns were identified for the combined soybean.
• The genetically modified soybean is as safe as comparator and non-GM reference varieties.
• No environmental safety concerns were identified, including in case of accidental release.

Conclusions:

• The two-event stack soybean GMB151 × DAS-44406-6 is safe for consumption and feed.
• No post-market monitoring for food/feed is deemed necessary.
• Environmental safety is confirmed, with monitoring plans aligned with intended use.