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Open- and closed-source LLMs in medical and engineering education.
Liping Sun1, Ya Li1, Hongxing Kan1
1School of Medical Informatics Engineering, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Frontiers in Medicine
|January 29, 2026
Summary
Open-source large language models (LLMs) show promise in education. Prompt engineering significantly boosts LLM accuracy for medical and engineering students, with DeepSeek excelling.
Area of Science:
- Artificial Intelligence in Education
- Open-Source Large Language Models (LLMs)
- STEM Education
Background:
- Large language models (LLMs) like GPT-4 are transforming education.
- Open-source LLMs offer accessibility and customization but are underused in medical and engineering fields.
- A systematic evaluation is needed to compare open-source and closed-source LLMs in these domains.
Purpose of the Study:
- To evaluate the performance of open-source LLMs (DeepSeek, GLM-4, Kimi) against GPT-4 for medical and engineering education.
- To investigate the impact of prompt engineering strategies on LLM accuracy.
- To highlight the potential of open-source LLMs in academic settings.
Main Methods:
- Comparative performance analysis of DeepSeek, GLM-4, Kimi, and GPT-4 across diverse question types.
- Implementation and testing of prompt engineering techniques (role-playing, generated knowledge prompting, chain-of-thought, few-shot, output style).
- Post-training accuracy assessment of LLM responses.
Main Results:
- DeepSeek demonstrated superior performance across all question types compared to other models.
- Prompt engineering significantly improved LLM accuracy, with DeepSeek achieving over 95% accuracy.
- Short-answer questions yielded the highest accuracy (up to 97%) across all four LLMs, underscoring prompt engineering's role.
Conclusions:
- Open-source LLMs, particularly DeepSeek, are effective tools for medical and engineering education.
- Prompt engineering is crucial for maximizing the utility of LLMs in academic problem-solving.
- Wider integration of open-source LLMs is recommended to bridge current evaluation gaps and enhance educational support.
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