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Exploring huntington's disease from a neurodevelopmental perspective

Chunhui Huang1, Xiao Zheng1, Wei Li1

  • 1The Sixth Affiliated Hospital of Jinan University, Dongguan, 523710, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China; Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.

International Journal of Biological Sciences
|January 29, 2026
PubMed
Summary

Huntington's disease (HD) may stem from developmental issues, not just neuron death. Targeting mutant huntingtin (HTT) during neurodevelopment offers new therapeutic avenues for this inherited neurodegenerative disorder.

Keywords:
HTTHuntington's diseaseanimal modelbrain organoidsearly interventionmHTTneurodevelopment

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