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Phage therapy against methicillin-resistant Staphylococcus pseudintermedius: a novel strategy for canine pyoderma

Xiancheng Feng1, Qingjie Du1, Keyi Wang1

  • 1The College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, Shaanxi, China.

Frontiers in Microbiology
|January 29, 2026
PubMed
Abstract

Insights

Phage therapy combined with antibiotics effectively treats canine pyoderma caused by multidrug-resistant Staphylococcus pseudintermedius (MRSP). This approach offers a promising alternative to antibiotics alone for combating resistant bacterial infections.

Area of Science:

  • Veterinary Microbiology
  • Bacteriophage Therapy
  • Antimicrobial Resistance

Background:

  • Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a significant threat due to multidrug resistance.
  • Bacterial phages offer a novel therapeutic avenue against resistant pathogens.

Purpose of the Study:

  • To investigate the efficacy of lytic phages and phage-antibiotic combinations against MRSP in canine pyoderma.
  • To establish an epidemiological dataset of multidrug-resistant S. pseudintermedius.

Main Methods:

  • Isolation and characterization of three high-efficiency lytic phages targeting MRSP.
  • Evaluation of phage and antibiotic efficacy in a canine pyoderma model.
  • Genomic and proteomic analyses to identify phage lysis mediators.

Main Results:

  • Phages enhanced MRSP susceptibility to antibiotics.
  • The phage-antibiotic combination demonstrated the most significant therapeutic effect.
  • Phage-only treatment was effective, while antibiotics alone showed no improvement over controls.

Conclusions:

  • Phage-antibiotic combinations represent a promising strategy for managing canine pyoderma.
  • This study contributes to public health by addressing antimicrobial resistance challenges.
Keywords:
methicillin-resistant Staphylococcus pseudintermediusmultidrug resistancephagespyodermatherapy

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