Related Experiment Video
Updated: May 8, 2026
08:03
Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism
Published on: July 5, 2014
Behavioral Variant in Alzheimer's Disease.
Chuang-Kuo Wu1, Jennifer M Dailey2, John E Donahue2
1Department of Neurology, Alzheimer's Disease and Memory Disorders Center, Providence, Rhode Island, USA.
Acta Neurologica Taiwanica
|January 29, 2026
Summary
This review details atypical Alzheimer's disease (AD) variants, focusing on the behavioral variant. It covers new diagnostic criteria and management strategies for improved clinical practice in neurology.
Area of Science:
- Neurology
- Neuroscience
- Geriatrics
Background:
- Alzheimer's disease (AD) typically presents with memory loss, but atypical variants exist.
- The behavioral variant of AD (bvAD) is characterized by prominent changes in personality and behavior.
- Understanding these variants is crucial for accurate diagnosis and effective management.
Purpose of the Study:
- To review the development and discovery of atypical variants in Alzheimer's disease.
- To provide a detailed comparison of the behavioral variant of AD with other AD presentations.
- To explain and apply newly developed diagnostic criteria and approaches for clinical neurology practice.
Main Methods:
- Literature review focusing on atypical Alzheimer's disease variants.
- Detailed description and comparison of the behavioral variant of AD.
- Explanation and application of novel diagnostic criteria and approaches.
- Case study analysis to illustrate pathophysiological variations.
Main Results:
- Atypical variants, particularly the behavioral variant of AD, are increasingly recognized.
- New diagnostic criteria and approaches enhance the identification of bvAD.
- Management and treatment principles for bvAD are outlined.
- Case reports highlight diverse pathophysiological pathways in bvAD.
Conclusions:
- Atypical variants of Alzheimer's disease, especially bvAD, require specific diagnostic and management strategies.
- The reviewed diagnostic criteria offer a framework for clinical application in neurology.
- Further research into the pathophysiology of bvAD is warranted.
Related Concept Videos
01:17Classification of Illness
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
01:22Alzheimer's Disease: Treatment
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
01:19Introduction to Psychological Disorders
Abnormal behavior, often referred to as mental illness, results from changes in brain function that influence thought patterns, behaviors, and social interactions. Psychologists and psychiatrists typically assess abnormal behavior using three primary criteria: deviance, maladaptation, and personal distress, particularly when these traits persist over long periods.
Deviant Behavior
Deviance in behavior refers to actions or thought patterns that significantly diverge from societal norms or...
Deviant Behavior
Deviance in behavior refers to actions or thought patterns that significantly diverge from societal norms or...
01:22Behavior Therapy
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
01:21Huntington Disease l: Introduction
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...