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Updated: Jan 31, 2026
09:20
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Heart Failure With Mildly Reduced Ejection Fraction: A Call for a Precision Medicine Approach.
Lingling Wu1, Affan Rizwan2, Mario Rodriguez3
1Cardiovascular Division, University of Alabama at Birmingham, Birmingham, Alabama, USA.
JACC. Advances
|January 29, 2026
Summary
Heart failure with mildly reduced ejection fraction (HFmrEF) is a complex condition. Precision medicine integrating advanced diagnostics and genomics offers a promising path to improve patient outcomes.
Area of Science:
- Cardiology
- Medical Diagnostics
- Genomics
Background:
- Heart failure with mildly reduced ejection fraction (HFmrEF) is a recognized, yet heterogeneous, heart failure phenotype.
- Understanding HFmrEF pathophysiology has advanced through new diagnostic tools and molecular profiling.
Purpose of the Study:
- To explore the evolving understanding and management strategies for HFmrEF.
- To highlight the potential of precision medicine in addressing HFmrEF heterogeneity.
Main Methods:
- Review of advances in diagnostic tools: strain imaging, cardiac MRI, molecular imaging.
- Integration of genomics and biomarker profiling for deeper pathophysiological insight.
- Analysis of recent studies and subgroup data for therapeutic options.
Main Results:
- Diagnostic and molecular advancements have improved the understanding of HFmrEF.
- Limited direct clinical evidence exists, but promising therapeutic options are emerging.
- Significant heterogeneity within HFmrEF necessitates individualized treatment approaches.
Conclusions:
- Future HFmrEF management should prioritize precision medicine and tailored care.
- Integrating advanced imaging, biomarkers, and genomics is crucial for optimizing outcomes.
- A precision-based approach can redefine care and improve prognosis for HFmrEF patients.
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