Related Experiment Video
Updated: Jan 31, 2026

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
Published on: February 14, 2025
Water-soluble platinum(II)-porphyrin based on oxygen response for cell hypoxia imaging
Meng-Yan Chai1, Yu-Li Dang2, He Qin1
1College of Science, Henan Agricultural University, Zhengzhou, 450002, People's Republic of China.
None:
Biomedical imaging has become an essential tool in the field of early cancer diagnosis and treatment. It is of great significance to develop a method that can monitor tumor hypoxia in real time and maintain a good photodynamic therapy (PDT) effect under hypoxic conditions. To achieve this goal, here we designed and synthesized a novel water-soluble porphyrin derivative, PtTSPP. The photophysical properties of PtTSPP were comprehensively characterized by UV-Vis absorption spectroscopy and fluorescence emission. This porphyrin has an extremely large Stokes shift and red emission (λem = 690 nm), which can effectively reduce the interference of background fluorescence and is used for the fluorescence imaging of HeLa cells. PtTSPP has good water solubility, is not prone to aggregation, and has a high singlet oxygen quantum yield. It also exhibits low dark toxicity and excellent photocytotoxicity. These properties make PtTSPP a promising candidate reagent for biomedical imaging and photodynamic therapy.
Related Concept Videos
Solubility Equilibria: Ionic Product of Water
The ionic product of water varies with temperature, and its value is 1.0 x 10−14 at standard experimental conditions. Per Le...
Solubility of Ionic Compounds
Factors Affecting Solubility
Solubility Equilibria
The...
Physical Properties Affecting Solubility
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
Water: A Bronsted-Lowry Acid and Base

