Bairui granules versus Reyanning granules in adults with acute bronchitis: a multicenter, randomized, double-blind,...

Area of Science:

• Integrative Medicine
• Respiratory Medicine
• Pharmacology

Background:

• Bairui granules, derived from Thesium chinense Turcz., are used for respiratory infections.
• High-quality evidence for Bairui granules in acute bronchitis is limited.
• Acute bronchitis is often treated with traditional Chinese medicine (TCM).

Purpose of the Study:

• To evaluate the effectiveness and safety of Bairui granules for acute bronchitis.
• To assess Bairui granules in patients with Wind-heat invading lung syndrome.
• To provide high-quality clinical evidence for Bairui granules in acute bronchitis.

Main Methods:

• A multicenter, randomized, double-blind, double-dummy, comparative trial (ChiCTR2200063906).
• 162 patients randomized to Bairui granules (experimental) or Reyanning granules (control) for 7 days.
• Primary endpoint: cough resolution rate; secondary endpoints: time to resolution, symptom scores, severity scores.

Main Results:

• Higher cough resolution rate in the Bairui group (72.22%) vs. control (35.19%) (P < 0.0001).
• Faster cough resolution time (144h vs. 168h, P = 0.001) and reduced cough severity (AUC, P = 0.023) with Bairui.
• Significant improvements in TCM symptom scores for cough, sputum, wind aversion, and sore throat observed in the Bairui group.
• Adverse event rates were similar and events were mild to moderate.

Conclusions:

• Bairui granules are more effective than Reyanning granules for acute bronchitis.
• Bairui granules demonstrate a higher cough resolution rate and faster symptom relief.
• The treatment with Bairui granules is well-tolerated and safe.