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METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant

Chunyu Feng1, Su-Ran Li1, Xiaoshuai Xu2

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, China.

Cell Reports
|January 29, 2026
PubMed

Keywords:
CD8(+) T cellCP: cancerCP: immunologyMETTL3cancer-associated fibroblastsglutamatehead and neck squamous cell carcinomaneoadjuvant immunochemotherapy

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