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Etiology, Epidemiology, and Pathogenesis of Müller-Weiss Disease-the Spanish Experience

Manuel Monteagudo1, Ernesto Maceira2

  • 1Orthopaedic and Trauma Department, Orthopaedic Foot and Ankle Unit, Hospital Universitario Quirónsalud Madrid; Faculty Medicine, Universidad Europea Madrid, Spain.

Foot and Ankle Clinics
|January 29, 2026
PubMed

Insights

Müller-Weiss disease (MWD) is more common in Spain than previously thought. Its pathogenesis likely involves navicular dysplasia, leading to flatfoot, impacting diagnosis and treatment.

Area of Science:

  • Orthopedics
  • Podiatry
  • Radiology

Background:

  • Müller-Weiss disease (MWD) is a rare, degenerative condition affecting the navicular bone.
  • Its true incidence and pathogenesis remain debated, particularly in Spain where it appears more prevalent.

Purpose of the Study:

  • To analyze the descriptions of Müller-Weiss disease (MWD) regarding etiology, epidemiology, and pathogenesis.
  • To clarify the fundamentals of MWD for improved management strategies.

Main Methods:

  • Literature review of MWD case descriptions.
  • Analysis of proposed etiologies, epidemiological data, and pathogenetic mechanisms.

Main Results:

  • MWD incidence in Spain may be underestimated compared to global reports.
  • Pathogenesis is suggested to involve navicular dysplasia, leading to altered foot biomechanics and flatfoot.
  • Accurate diagnosis is crucial, as not all reported cases represent true MWD.

Conclusions:

  • MWD pathogenesis likely involves navicular dysplasia causing biomechanical changes.
  • Correct identification of MWD is essential for accurate epidemiology and effective treatment.
  • Further research is needed to fully elucidate MWD etiology and pathogenesis.
Keywords:
Avascular necrosisEpidemiologyEtiologyMüller-Weiss diseasePathogenesisTarsal navicular

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