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EIF4A3-Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1.

Jin Li1,2, Bing Jin1,2, Yuwei Yan1,2

  • 1Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Sciences, Shanghai University, Nantong, China.

Journal of Cachexia, Sarcopenia and Muscle
|January 30, 2026
PubMed
Summary
This summary is machine-generated.

Circular RNA circSnd1 promotes muscle atrophy and aging by stabilizing EEF1A1 protein. Inhibiting circSnd1 ameliorates muscle wasting, offering a potential therapeutic target for muscle atrophy.

Keywords:
EEF1A1 ubiquitinationEIF4A3FAT10circSnd1muscle ageingmuscle atrophy

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Gerontology

Background:

  • Muscle atrophy is a significant complication of aging and chronic diseases.
  • Current therapeutic interventions for muscle atrophy are limited.
  • The role of circular RNAs (circRNAs) in muscle atrophy remains largely unexplored.

Purpose of the Study:

  • To investigate the function and mechanism of circSnd1 in muscle atrophy and aging.
  • To identify circRNAs involved in muscle wasting.

Main Methods:

  • circRNA sequencing and quantitative real-time PCR in muscle atrophy models and aged muscle.
  • Gain-of-function and loss-of-function experiments to assess circSnd1's role.
  • RNA immunoprecipitation followed by mass spectrometry (RIP-MS) and RIP assay to elucidate molecular mechanisms.

Main Results:

  • circSnd1, a conserved circRNA from the SND1 gene, is upregulated in muscle atrophy models and aged human and mouse muscle.
  • circSnd1 promotes muscle atrophy and aging in cellular and animal models.
  • circSnd1 expression is regulated by EIF4A3 and promotes muscle atrophy by stabilizing EEF1A1 protein via the FAT10 interaction, reducing EEF1A1 ubiquitination.

Conclusions:

  • circSnd1 is identified as a novel circRNA that promotes muscle atrophy and aging.
  • circSnd1 represents a potential therapeutic target for combating muscle wasting conditions.