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Therapeutic Update on Topical Steroid Withdrawal.
1From the University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Dermatitis : Contact, Atopic, Occupational, Drug
|January 30, 2026
Summary
Topical steroid withdrawal syndrome (TSW) is an iatrogenic condition linked to prolonged corticosteroid use. This review examines current TSW treatments, highlighting the need for evidence-based therapies.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical steroid withdrawal syndrome (TSW) is an iatrogenic condition increasingly reported in patients following prolonged topical corticosteroid use.
- TSW is often under-recognized due to lack of formal diagnostic criteria and overlap with atopic dermatitis (AD).
Purpose of the Study:
- To review current and emerging treatments for TSW.
- To provide clinicians and patients with a reference for TSW management options.
- To identify gaps in evidence and call for further research.
Main Methods:
- Literature review of pharmacologic therapies, natural products, lifestyle interventions, and alternative approaches for TSW.
- Analysis of existing clinical evidence for TSW treatments.
Main Results:
- A wide range of treatments are being used or studied for TSW.
- Few TSW treatment strategies are supported by rigorous clinical evidence.
- Current TSW management includes pharmacologic, natural, lifestyle, and alternative therapies.
Conclusions:
- There is a growing need for evidence-based therapies for TSW.
- Further research is required to validate TSW treatment options.
- Clinicians and patients need a clear reference for managing TSW.
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