Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Random Sampling Method01:09

Random Sampling Method

14.6K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest. Among the various sampling methods used by...
14.6K
Causality in Epidemiology01:21

Causality in Epidemiology

1.6K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.7K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

247
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
247
Random Error01:04

Random Error

9.8K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K
Random Variables01:09

Random Variables

17.8K
A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific effects of depression on the incidence and risk factors for coronary heart disease: insights from multi-omics approaches.

European journal of preventive cardiology·2026
Same author

Association Between Systemic Inflammation Response Index, Worsening of Left Ventricular Systolic Function and Prognosis in Patients with Coronary Artery Disease.

Journal of inflammation research·2026
Same author

Cardiovascular Screening and Clearance Pathways for Recreational Athletes: Beyond the Elite.

JACC. Case reports·2026
Same author

Boosting Upconversion through Selective Interfacial Energy Transfer toward Infrared Sub-bandgap Photodetection.

Nano letters·2026
Same author

Exploring the potential impact of TNF-α inhibition on major depressive disorder risk: Insights from a prospective cohort and genetic evidence.

Brain, behavior, and immunity·2026
Same author

Excess apolipoprotein B predicts long-term survival in statin-treated CAD irrespective of achieved LDL-C levels: a pooled cohort analysis.

Lipids in health and disease·2026

Related Experiment Video

Updated: Jan 31, 2026

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

1.8K

Decoding Causal Associations Between Neuropsychiatric Disorders and Rotator Cuff Tendinopathy: A Two-Sample Mendelian

Weizhe Zhang1, Ming Chen2, Haozhang Huang3

  • 1Department of Joint Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou City, Guangdong Province, China.

Brain and Behavior
|January 30, 2026
PubMed
Summary

Genetic links between attention deficit/hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) increase rotator cuff tendinopathy (RCT) risk. Early screening and targeted prevention are recommended for these populations.

More Related Videos

Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft
07:22

Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft

Published on: June 6, 2025

645
A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears
06:41

A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears

Published on: January 13, 2026

80

Related Experiment Videos

Last Updated: Jan 31, 2026

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

1.8K
Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft
07:22

Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft

Published on: June 6, 2025

645
A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears
06:41

A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears

Published on: January 13, 2026

80

Area of Science:

  • Orthopedics
  • Psychiatry
  • Genetics

Background:

  • Rotator cuff tendinopathy (RCT) affects millions globally, necessitating effective treatment strategies.
  • Neuropsychiatric disorders (ND) share underlying pathways with tendinopathy, but causal links remain unclear.
  • Understanding genetic associations can inform personalized treatments and injury prevention for ND patients at risk of RCT.

Purpose of the Study:

  • To investigate the genetic association between eight major neuropsychiatric disorders (ND) and rotator cuff tendinopathy (RCT).
  • To establish potential causal relationships using a bidirectional two-sample Mendelian randomization (MR) approach.
  • To identify specific ND that confer an increased genetic risk for developing RCT.

Main Methods:

  • Utilized genome-wide association studies (GWAS) data for ADHD, ASD, BD, epilepsy, MDD, OCD, PTSD, SCZ, and RCT in European ancestry.
  • Employed bidirectional two-sample Mendelian randomization (MR) analyses to assess causal links.
  • Conducted sensitivity analyses (MR-Egger, weighted median, CAUSE) and multivariable MR adjusting for confounders.

Main Results:

  • Genetic predisposition to ADHD and PTSD significantly increased RCT risk (OR 1.14 and 2.23, respectively).
  • Major depressive disorder (MDD) showed a similar association, but it was attenuated after confounder adjustment.
  • Multivariable MR confirmed ADHD and PTSD as robust causal factors for RCT, even after adjusting for lifestyle and socioeconomic factors.

Conclusions:

  • Attention deficit/hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) are genetically associated with an increased risk of rotator cuff tendinopathy (RCT).
  • Findings highlight the need for early screening and targeted overuse injury prevention in individuals with ADHD and PTSD.
  • Specialized clinical interventions may help alleviate the RCT burden in these at-risk populations.