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Published on: January 28, 2020

Association Between Systemic Inflammation Response Index, Worsening of Left Ventricular Systolic Function and

Huangtao Ruan1,2, Xiaozhao Lu2,3, Huan Lu2,3,4

  • 1Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Journal of Inflammation Research
|May 7, 2026
PubMed

Insights

High systemic inflammation response index (SIRI) is linked to worsening left ventricular systolic function in coronary artery disease (CAD) patients. This worsening also contributes to cardiovascular and all-cause mortality in CAD.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Echocardiography

Background:

  • Inflammation is a key factor in coronary artery disease (CAD) progression and poor prognosis.
  • Worsening left ventricular (LV) systolic function significantly impacts CAD patient outcomes.
  • The direct link between inflammation and the decline of LV systolic function in CAD remains unclear.

Purpose of the Study:

  • To investigate the association between the systemic inflammation response index (SIRI) and the worsening of LV systolic function in patients with CAD.
  • To determine if worsening LV systolic function mediates the relationship between SIRI and mortality in CAD patients.

Main Methods:

  • Retrospective analysis of patients from the Cardiorenal Improvement-II study (2007-2020) with baseline and follow-up echocardiograms.
  • Stratification of patients into four groups based on SIRI quartiles.
  • Primary endpoint: a ≥10% decrease in LV ejection fraction within 12 months post-discharge.
  • Secondary endpoints: cardiovascular and all-cause mortality, analyzed using logistic regression and mediation analysis.

Main Results:

  • Out of 6307 CAD patients, 8.3% experienced worsening LV systolic function within a year.
  • Patients in the highest SIRI quartile (Q4, ≥2.61) showed a significantly higher risk of worsening LV systolic function (aOR: 1.52, P=0.003).
  • Worsening LV systolic function mediated 4.0% of the association between SIRI and cardiovascular mortality, and 2.0% with all-cause mortality.

Conclusions:

  • Elevated SIRI is a significant risk factor for the deterioration of LV systolic function in CAD patients.
  • The decline in LV systolic function associated with high SIRI contributes to increased mortality.
  • Targeting inflammation through anti-inflammatory treatments may offer a therapeutic strategy to improve outcomes for CAD patients.
Abstract

Keywords:
coronary artery diseaseinflammationleft ventricular functionprognosissystemic inflammation response index

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