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Vedolizumab induced acute interstitial nephritis
Darren Fernandes1, Alok Mathew1, Alastair Ferraro2
1The Department of Gastroenterology, Nottingham Digestive Diseases Centre, Derby Road, Nottingham, NG7 2UH, United Kingdom.
Oxford Medical Case Reports
|January 30, 2026
Summary
Vedolizumab, used for ulcerative colitis (UC), can rarely cause acute interstitial nephritis. Discontinuation of vedolizumab and steroid treatment led to kidney function recovery in a UC patient.
Area of Science:
- Gastroenterology and Nephrology
- Immunology and Pharmacology
Background:
- Vedolizumab is a gut-selective anti-integrin monoclonal antibody with a well-established safety profile for ulcerative colitis (UC).
- Unusual complications associated with vedolizumab therapy require careful monitoring and awareness among gastroenterologists.
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