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Single-cell epigenomics and proteomics methods integrated in multiomics.

Haiyue Bi1,2, Xiaocheng Weng1,2

  • 1Department of Clinical Laboratory, Center for Gene Diagnosis, and Program of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Fundamental Research
|January 30, 2026
PubMed
Summary
This summary is machine-generated.

Single-cell multiomics integrates genomic, epigenomic, and proteomic data to reveal cellular heterogeneity and regulatory networks. These advanced techniques offer new insights into cell function, development, and disease states.

Keywords:
Cellular heterogeneityEpigenomeMultimodal omicsProteomeSingle-cell multiomicsTranscriptomics

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Area of Science:

  • Single-cell biology
  • Multiomics analysis
  • Genomics and epigenomics

Background:

  • Cellular heterogeneity is crucial for understanding biological processes.
  • Single-cell analysis provides high-resolution insights into cellular mechanisms.
  • Multimodal single-cell techniques are essential for deciphering complex biological systems.

Purpose of the Study:

  • To review single-cell separation techniques for multiomics.
  • To discuss methods combining epigenetics and gene expression at single-cell resolution.
  • To explore joint analysis of proteins and transcriptomes in single cells.

Main Methods:

  • Single-cell isolation techniques.
  • Multiomics data integration (genomics, epigenomics, transcriptomics, proteomics).
  • Analysis of DNA methylation, chromatin accessibility, histone modifications, and protein expression.

Main Results:

  • Identification of cell subpopulations and developmental trajectories.
  • Elucidation of gene regulatory networks and cellular phenotypes.
  • Enhanced understanding of cell-to-cell communication.

Conclusions:

  • Single-cell multiomics is a powerful tool for studying cellular heterogeneity.
  • Advances in multimodal single-cell techniques are crucial for biological discovery.
  • The field presents significant challenges and opportunities for future research.