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Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome (Review).
Hanyue Ying1, Ke Zhang1, Yu Chen2
1Department of Radiation Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310006, P.R China.
Oncology Letters
|January 30, 2026
Summary
Tumor hyperthermia, a treatment using heat, boosts cancer therapy effectiveness when combined with radiation and chemotherapy. It works by inhibiting DNA repair and improving tumor oxygenation, showing significant clinical benefits.
Area of Science:
- Oncology
- Radiation Oncology
- Cancer Therapy
Background:
- Tumor hyperthermia has been clinically used for nearly 40 years.
- It is an effective adjunct to radiotherapy and chemotherapy for primary and recurrent tumors.
Purpose of the Study:
- To explore the synergistic mechanisms between radiotherapy and hyperthermia.
- To review clinical trial outcomes and optimize hyperthermia's application.
Main Methods:
- Review of in vitro and in vivo experiments.
- Analysis of randomized, non-randomized, and observational clinical studies.
Main Results:
- Hyperthermia acts as a radiosensitizer by inhibiting DNA repair.
- It reduces tumor hypoxia and enhances drug uptake, perfusion, and oxygenation.
- Clinical studies provide substantial evidence for the benefits of combined hyperthermia and radiotherapy.
Conclusions:
- Combining hyperthermia with radiotherapy offers significant therapeutic advantages.
- Optimizing clinical application of hyperthermia is crucial for enhancing cancer treatment outcomes.
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