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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides
Xuefei Jing1, Jen Suh1, Joshua Maxwell2
1School of Life and Environmental Sciences, University of Sydney, NSW 2006, Australia. joel.mackay@sydney.edu.au.
None:
The large size of macrocyclic peptides discovered by mRNA display can hinder therapeutic development. Using size-restricted RaPID libraries and analysis of 40 published datasets, we show that potent binders are more reliably identified from libraries with at least nine randomised residues, providing guidance for mRNA display screen design.
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