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Lab-on-a-chip for biomarker detection: advances, practical applications, and future perspectives.

Tianfeng Xu1,2, Hao Bai1,2, Jie Hu1

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Lab-on-a-chip (LoC) technology revolutionizes biomarker detection with miniaturized, automated assays. These advanced microfluidic devices offer high sensitivity and portability for early disease screening and precision medicine.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Microfluidics

Background:

  • Lab-on-a-chip (LoC) technology integrates analytical processes into single microfluidic devices.
  • Advances in microfabrication and fluid dynamics enable miniaturized, automated assays with high sensitivity, rapid analysis, and portability.

Purpose of the Study:

  • To review recent progress in Lab-on-a-chip (LoC) based biomarker detection.
  • To highlight innovations in fabrication, assay integration, and practical applications of LoC systems.
  • To discuss challenges and future directions for LoC technology in diagnostics.

Main Methods:

  • Review of recent scientific literature on Lab-on-a-chip (LoC) technology for biomarker detection.
  • Analysis of innovations in microfabrication, fluid dynamics, and assay integration.
  • Examination of diverse applications in cancer screening, infectious disease diagnostics, and health monitoring.

Main Results:

  • LoC systems demonstrate high sensitivity, rapid analysis, and portability for various applications.
  • Integration with multi-omics approaches enhances understanding of complex disease mechanisms.
  • Innovations in materials, architecture, and system integration promise improved diagnostic performance.

Conclusions:

  • Lab-on-a-chip (LoC) technology is a transformative platform for biomarker detection.
  • Continued innovation will enhance diagnostic performance, cost-effectiveness, and reliability.
  • LoC technology is poised to shape the future of precision diagnostics.