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Published on: July 28, 2022
Mechanochemistry-Enhanced Regioselective Hydrophosphinylation of Acrylamides and Enamides
Zi-Kui Liu1,2, Yun-Kun Su2, Cong-Fang Cheng2
1Department of Otolaryngology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei 430071, China.
Abstract:
Herein, we report a ball milling technique for the regioselective hydrophosphinylation of acrylamides and enamides, utilizing readily available Ph2PCl as the phosphine source and H2O as an additive under metal-free and toxic solvent-free conditions. Michael-type and Markovnikov hydrophosphinylation reactions have been achieved for acrylamides and enamides, respectively. The reaction features broad substrate scope, sustainable conditions and high atom economy, facilitating the rapid assembly of structurally diverse amide-based phosphine oxides in useful to good yields.
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