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Updated: Jan 31, 2026

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Efficacy of Ipflufenoquin against Strawberry Gray Mold: Insights from AlphaFold- Based Structural Modeling and

Sungyu Choi1, Doeun Son1, Hyeong-Rok Jang1

  • 1Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.

Journal of Agricultural and Food Chemistry
|January 30, 2026
PubMed

Insights

Ipflufenoquin effectively controls strawberry gray mold, even resistant strains. However, it alters the fungal community, impacting sustainable disease management strategies.

Area of Science:

  • Plant Pathology
  • Mycology
  • Agricultural Science

Background:

  • Gray mold, caused by *Botrytis cinerea*, poses a significant threat to strawberry production.
  • Fungal resistance to existing fungicides necessitates the development of novel control agents.

Purpose of the Study:

  • To evaluate the efficacy of ipflufenoquin, a new dihydroorotate dehydrogenase (DHODH) inhibitor, against *Botrytis cinerea* and other strawberry pathogens.
  • To investigate the molecular mechanisms of ipflufenoquin's action and its impact on the fungal community.

Main Methods:

  • *In vitro* sensitivity assays and field trials were conducted to assess ipflufenoquin's efficacy.
  • Structural modeling (AlphaFold2) and molecular docking were used to determine ipflufenoquin's binding site on DHODH.
  • RNA-sequencing (RNA-seq) analysis was performed to understand the transcriptomic response to ipflufenoquin treatment.

Main Results:

  • Ipflufenoquin showed high *in vitro* sensitivity against *B. cinerea* and broad-spectrum activity against other tested pathogens.
  • Field and greenhouse trials confirmed ipflufenoquin's robust control of gray mold, including fungicide-resistant isolates.
  • Ipflufenoquin treatment led to a shift in the fungal community, favoring less sensitive genera, and induced stress responses in fungi.

Conclusions:

  • Ipflufenoquin is a potent fungicide for managing strawberry gray mold, offering a new option against resistant strains.
  • Understanding ipflufenoquin's molecular interactions and effects on fungal communities is crucial for developing sustainable disease management strategies.
Keywords:
DHODH inhibitorRNA-seqalphafold2gray moldipflufenoquinmolecular dockingstrawberry

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