Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

598
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
598
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

452
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
452
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.6K
X-linked Traits01:19

X-linked Traits

58.6K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.6K
Neural Regulation01:37

Neural Regulation

43.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.4K
What is Behavior?00:54

What is Behavior?

10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep brain stimulation for the treatment of patients with dystonia: advances towards network-based personalised care.

The Lancet. Neurology·2026
Same author

Repeat Ipsilateral Focused Ultrasound Thalamotomy after Tremor Recurrence: Safety, Efficacy, and Lesion Analysis.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial.

Human brain mapping·2026
Same author

Human hippocampal ripples tune cortical responses based on predicted uncertainty.

Nature neuroscience·2026
Same author

A prognostic human brain network for diffuse midline glioma.

Nature·2026
Same author

Prevalence and Clinical Correlates of Psychiatric Disorders in a Hispanic-Majority Inflammatory Bowel Disease Cohort.

Cureus·2026

Related Experiment Video

Updated: Feb 1, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.9K

Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics.

Young-Hoon Nho1, Liming Qiu1, Robert L Seilheimer2

  • 1Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Cell
|January 30, 2026
PubMed
Summary

Researchers found elevated low-gamma power in the anteromedial orbitofrontal cortex (OFC) during obsessive-compulsive disorder (OCD) symptom states. This OFC gamma activity was reduced by deep brain stimulation, offering new biomarkers for OCD interventions.

Keywords:
DBSOCDOFCdeep brain stimulationintracranial monitoringobsessive-compulsive disorderorbitofrontal cortexsEEGstereo-electroencephalography

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.1K
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

29.9K

Related Experiment Videos

Last Updated: Feb 1, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.9K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.1K
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice
06:50

Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice

Published on: December 24, 2013

29.9K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Computational Neuroscience

Background:

  • Aberrant orbitofrontal cortex (OFC) activity is linked to obsessive-compulsive disorder (OCD) symptom severity.
  • Identifying real-time biomarkers for OCD symptoms is crucial for developing personalized treatment strategies.

Purpose of the Study:

  • To investigate high-resolution neurophysiologic markers of OCD symptom dynamics within the human OFC.
  • To explore the relationship between OFC neural activity and moment-to-moment OCD symptom expression.

Main Methods:

  • Intracranial monitoring was used to record neurophysiologic activity in the OFC during a symptom provocation task in individuals with OCD.
  • Low-gamma power in the anteromedial OFC was analyzed in relation to symptom severity.
  • The effect of ventral basal ganglia electrical stimulation on OFC gamma activity and OCD symptoms was assessed.

Main Results:

  • Low-gamma power in the anteromedial OFC was significantly elevated during periods of high OCD symptom intensity.
  • Electrical stimulation of the ventral basal ganglia, known to alleviate OCD symptoms, also led to a reduction in anteromedial OFC gamma power.

Conclusions:

  • Anteromedial OFC low-gamma activity serves as a neural correlate for the dynamic expression of OCD symptoms.
  • These findings provide mechanistic insights into OFC involvement in OCD and support targeted neuromodulation strategies like deep brain stimulation.