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Related Experiment Video

Updated: Feb 1, 2026

Visually Sexing Loggerhead Shrike Lanius Ludovicianus Using Plumage Coloration and Pattern

Visually Sexing Loggerhead Shrike Lanius Ludovicianus Using Plumage Coloration and Pattern

Published on: March 8, 2020

The human pathome shows sex and tissue specific aging patterns.

Michael Ben Ezra^1,2, Jonas Bach Garbrecht³, Nasya Rasmussen³

¹Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenahgen, Denmark. mbenezra@sund.ku.dk.

|January 30, 2026

Summary

Researchers analyzed 33 million histological samples to understand aging. They identified nintedanib as a potential intervention, showing it reduces senescence and extends lifespan in fruit flies.

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Last Updated: Feb 1, 2026

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Published on: May 24, 2014

Area of Science:

Biogerontology
Computational Pathology
Digital Health

Background:

Tissue-specific aging mechanisms in humans remain largely uncharacterized.
Large-scale analysis of histological data can reveal aging patterns.

Purpose of the Study:

To identify age- and mortality-associated features from histological sample descriptions.
To discover potential interventions for human aging.

Main Methods:

Utilized text narratives from 33 million histological samples.
Applied unsupervised topic modeling to identify predictive terms for age and mortality.
Cross-referenced identified terms in PubMed to find potential interventions.

Main Results:

Developed The Human Pathome database, extracting thousands of aging-related features.
Observed sexual dimorphism in aging onset and progression.
Identified nintedanib as a potential aging intervention.
Demonstrated nintedanib's efficacy in reducing cellular senescence markers, pro-fibrotic pathways, and extending lifespan in Drosophila melanogaster.

Conclusions:

Population text datasets are valuable resources for discovering novel aging interventions.
Nintedanib shows promise as a therapeutic agent for age-related conditions.