Effect of atropine on cerebrovascular responsiveness to carbon dioxide

Effects of cholinergic inhibition by atropine on cerebral circulation were studied in 15 baboons anesthetized with sodium pentobarbital. Intravertebral infusion of atropine, 0.1 mg/kg, did not cause any changes in cerebral blood flow (CBF), superior sagittal sinus wedge pressure (SSWP), epidural pressure (EDP), cerebral perfusion pressure, or cerebral vascular resistance under normal conditions. Cerebrovascular responsiveness to carbon dioxide (CO2) inhalation was not influenced by atropine. The presence of cholinergic nerve fibers has been proved in the cerebral blood vessels and the existence of cholinergic mechanism suggested in the brain stem, but it is not likely that the cholinergic nerves have tonic control of cerebral blood vessels in the resting state or affect cerebrovascular responsiveness to CO2. The changes in EDP and those in SSWP showed a very good correlation to each other. There was also a good correlation between the changes in CBF and those in EDP or SSWP.