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Advanced imaging strategies in cardiac organoids: bridging the gap between structural complexity and functional
Keyan Zhao1, Bihua Tang2, Renjun Gu3
1School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Cardiovascular Diabetology
|January 31, 2026
Summary
Cardiac organoids offer advanced cardiovascular disease research models. This review details imaging techniques for studying cardiac organoid complexity and disease mechanisms, highlighting future directions for dynamic imaging.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Organoid Technology
Background:
- Cardiac organoids are crucial for cardiovascular disease research and drug development.
- They mimic the in vivo cardiac microenvironment, structure, and function.
- Imaging technologies are essential for analyzing their complex three-dimensional (3D) structure.
Purpose of the Study:
- To review the framework of cardiac organoid imaging research.
- To focus on sample processing, imaging technologies, and analysis workflows.
- To provide guidelines for selecting imaging techniques based on research goals.
Main Methods:
- The review outlines key aspects of cardiac organoid imaging.
- It covers pre-imaging sample preparation, mainstream imaging modalities, and image analysis.
- Applications in disease mechanisms and drug screening are discussed.
Main Results:
- Cardiac organoid imaging research involves sample processing, technology selection, and data analysis.
- Current imaging techniques enable the study of cardiac organoid structure and function.
- Guidelines for technique selection are provided based on specific research objectives.
Conclusions:
- Cardiac organoid imaging is vital for understanding cardiovascular diseases.
- Long-term 4D imaging of cardiac organoids is an emerging area.
- Future advancements in high-resolution dynamic imaging are needed to explore cardiac pathology dynamics.
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