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Sponsorship Bias in Randomised Controlled Trials on Postoperative Pain After Third Molar Extraction: A Meta-Research
Carlos Eduardo Dutra Rufato1, Mayara Colpo Prado1, Bernardo Antonio Agostini1
1Graduate Program in Dentistry, ATITUS Educação, Passo Fundo, Rio Grande do Sul, Brazil.
European Journal of Pain (London, England)
|January 31, 2026
Summary
Sponsorship did not influence positive results or selective outcome reporting in randomized controlled trials for third molar extraction pain management. Industry-funded and non-sponsored studies offer comparable evidence for clinical decisions.
Area of Science:
- Pharmacology and Anesthesiology
- Clinical Trial Methodology
- Evidence-Based Medicine
Background:
- Investigating pharmacologic interventions for postoperative pain management after third molar extraction.
- Assessing potential bias in reporting of positive results and selective outcome reporting (SOR) in randomized controlled trials (RCTs).
Purpose of the Study:
- To evaluate whether sponsorship influences the reporting of positive results and the occurrence of selective outcome reporting (SOR) in RCTs for third molar extraction pain management.
Main Methods:
- Meta-research analysis of 430 RCTs comparing pharmacologic interventions for postoperative pain.
- Searches conducted in PubMed, Scopus, and Web of Science; study selection and data extraction performed by two independent reviewers.
- Assessment of SOR by comparing registered protocols with published outcomes; analysis of associations between sponsorship and reporting using chi-square test.
Main Results:
- No statistically significant association was found between sponsorship status and selective outcome reporting (p=0.861).
- No statistically significant association was found between sponsorship status and the reporting of positive results (p=0.241).
Conclusions:
- Sponsorship status was not associated with selective outcome reporting or the likelihood of reporting positive results in RCTs on postoperative pain management after third molar extraction.
- Industry-funded and non-sponsored studies provide comparably reliable evidence, supporting unbiased clinical decisions in third molar surgery pain management.
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