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Flight rules for clinical AI: lessons from aviation for human-AI collaboration in medicine
Ariel Yuhan Ong1,2,3, David A Merle4,5,6, Andreas Pollreisz7
1NIHR Moorfields Biomedical Research Centre, London, UK. ariel.ong@nhs.net.
NPJ Digital Medicine
|January 31, 2026
Summary
Artificial intelligence (AI) in medicine offers potential but also risks. Learning from aviation's automation journey, the medical field should view AI as a "digital copilot" for safer patient care.
Area of Science:
- Medical technology
- Human-computer interaction
- Patient safety
Background:
- The aviation industry has valuable lessons from integrating automation, which improved safety but introduced new risks.
- Early automation in aviation led to over-reliance and unforeseen vulnerabilities, necessitating robust safety frameworks.
- Artificial intelligence (AI) is increasingly being adopted in clinical settings, mirroring aviation's automation trajectory.
Purpose of the Study:
- To draw parallels between aviation automation lessons and the integration of AI in medicine.
- To propose a framework for safe and effective AI implementation in healthcare.
- To advocate for a collaborative human-AI model in clinical practice.
Main Methods:
- This perspective draws on the experiences of clinicians and aviation safety experts.
- It analyzes historical data and safety frameworks from the aviation industry.
- It proposes a conceptual shift in how AI is perceived and utilized in medicine.
Main Results:
- Viewing AI as a "digital copilot" rather than an "autopilot" is crucial for safe integration.
- Practical considerations like scenario-based training and clinician benchmarking are essential.
- Minimum unaided practice is necessary to maintain core clinical skills.
Conclusions:
- The medical community must proactively learn from aviation's automation experiences to ensure patient safety.
- Adopting a human-AI collaboration model, supported by specific training and practice guidelines, will optimize AI's role in healthcare.
- This approach aims to enhance patient care by leveraging AI effectively while mitigating its inherent risks.
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