Related Experiment Video
Updated: Feb 3, 2026
06:23
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
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Novel Insights into Immune Cell Function in Type 2 Diabetes Mediated by Gut Microbiota: A Two-Sample Mendelian
Zeyu Zhou1,2, Zenghui Liu3, Siming Wang1,2
1Department of Clinical Laboratory, Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
Endocrine, Metabolic & Immune Disorders Drug Targets
|February 1, 2026
Summary
Gut microbiota plays a key role in type 2 diabetes mellitus (T2DM) by mediating the relationship between immune cells and T2DM. This study identifies specific gut bacteria that influence immune cell interactions, offering new avenues for T2DM prevention.
Area of Science:
- Immunology
- Microbiome research
- Metabolic disease research
Background:
- Immune cell involvement in type 2 diabetes mellitus (T2DM) is known, but interactions with gut microbiota remain unclear.
- Understanding these interactions is crucial for elucidating T2DM pathogenesis.
Purpose of the Study:
- To investigate the mediating role of gut microbiota in the relationship between immune cell phenotypes and T2DM.
- To identify specific gut microbiota species that influence immune cell function in the context of T2DM.
Main Methods:
- Utilized Mendelian randomization (MR) analysis with large-scale genetic and phenotypic data from European and Finnish populations.
- Analyzed 731 immune cell phenotypes, 473 gut microbiota traits, and T2DM data.
- Employed single-nucleotide polymorphisms (SNPs) as instrumental variables to infer causal relationships.
Main Results:
- Identified 36 immune cell phenotypes and 10 gut microbiota traits significantly associated with T2DM.
- Revealed that five gut microbiota species mediate the link between specific immune cells (e.g., CD3, Treg, CD4+ cells) and T2DM.
- Demonstrated partial mediation by Bacillus AY for effects of CD3 on Treg and CD4+ cells in T2DM.
Conclusions:
- Gut microbiota significantly mediates the relationship between immune cells and T2DM.
- Findings provide novel insights into the complex interplay of host immunity and gut microbiome in T2DM.
- Highlights potential targets for early T2DM prevention and therapeutic interventions.
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